Scientific Programme

15.00-19.00 | Registration Open

17.00-17.45 | Opening Session Including Keynote Address

Chairs: Dr Nizar Mahlaoui and Martine Pergent

17.45-19.00 | Session 1: Use of AI Tools to Improve the Clinical Management of Immunodeficiencies 

Chairs: Prof Siobhan Burns and Prof Adli Ali

  • Lecture 1: An Artificial Intelligence Framework for Personalised Early and Timely Diagnosis and Prognosis of PIDs – Dr Nicholas Rider
  • Lecture 2: AI Tools for Early Detection of Bronchiectasis – Dr Daan Caudri
  • Lecture 3: Use of Human Phenotype Ontology and AI in Clinical Practice to Improve Diagnosis and Treatment for Primary Immunodeficiency Disorders – Dr Maaike Kusters

19:15 | Welcome Reception 

07.30-08.30 | Industry-Sponsored Symposium

08.00-08.30 | Guided Poster Walk 1:

  • Leveraging AI and Disruptive Technologies for Data-Driven Advances in PID Clinical Care, guided by Prof Adli Ali
  • Diagnosis and Newborn Screening Advances, guided by Prof Pamela Lee

08.30-10.00 | Session 2: Precision Pathways: Innovating Targeted Therapies

Chairs: Prof Stuart Tangye and Prof Tadej Avcin

  • Video: Living with Stat-3 Deficiency – Patient Representative
  • Lecture 1: JAK Inhibitors Treatment in IEI – Dr Carsten Speckmann
  • Lecture 2: The Role of  Interferon Gamma in HLH – Dr Fabrizio de Benedetti
  • Lecture 3: Targeted Therapies for Monogenic Inborn Errors of Immunity – Prof Paolo Palma

10.00-10.30 | Coffee Break and Guided Poster Walk 2

  • PID Treatment Advances (Personalised Treatments, Targeted Therapies, Gene Therapies, Novelties in Ig Replacement Therapy…) guided by Prof Fabio Candotti
  • Life with PID – Insights and Quality of Life guided by Nurse Patricia Luck

10.30-12.00 | Session 3: Secondary Immunodeficiencies

Chairs: Dr Virgil Dalm and Whitney Ayoub Goulstone

  • Lecture 1: Overlapping Primary and Secondary Immunodeficiencies in Haematological Cancer – Prof Silvia Sanchez-Ramon
  • Lecture 2: B-cell and non-B-cell Targeted Immunomodulation Causing Immunodeficiencies – Dr Sara Barmettler
  • Lecture 3: Optimal Ig Therapy Regimen for SID (when to start, dosage, when to stop) – Prof Stephen Jolles
  • Lecture 4: Nursing Perspective on Holistic Treatment of the SID Patients – Nurse Emily Carne

12:00-13:00 | Industry-Sponsored Symposium

13:00-14:00 | Industry-Sponsored Symposium

13.00-14.15 | Lunch and Poster Walk

14.15-15.45 | Session 4: Pathogen Paradox – Tackling Complex Infections in the Immunodeficient Patient (Case studies)

Chairs: Prof Anna Sediva and Prof Charlotte Cunningham-Rundles

  • Opening Video: Facing Recurrent Severe Infection – Patient Representative 
  • Lecture 1: Current Challenges and Opportunities in Infection in Immune Deficiency – Dr David Lowe
  • Lecture 2: Poliovirus and the IEIs – Where are we today? – Prof Surjit Singh
  • Lecture 3: Case study: Refractory Non-tuberculosis Mycobacteria Infections in Patients with IFNg Antibodies – Prof Jettanong Klaewsongkram
  • Lecture 4: Case study: CARD9 Deficiency and Brain Fungal Disease – Dr Lionakis Michail

15.45-16.15 | Coffee Break and Guided Poster Walk 3

16.15-17.30 | Session 5: Breaking Topics from Around the World

Chair: Dr Anne Barasa and Dimas Sugiharto

  • Lecture 1: Asia Pacific Society for Immunodeficiencies (APSID) – XLA HSCT vs IgRT – Prof Pamela Lee
  • Lecture 2: African Society for Immunodeficiencies (ASID) – Haploidentical HSCT in Tunisia – Prof Monia Ouederni
  • Lecture 3: Latin American Society for Immunodeficiencies (LASID) – Newborn Screening – Dr Lorena Regairaz
  • Lecture 4: Clinical Immunology Society (CIS) – The Impact of Newborn Screening on Racial and Ethnic Disparities in SCID HSCT Outcomes – Prof Elie Haddad
  • Lecture 5: European Society for Immunodeficiencies (ESID) – Challenges of Access to Gene Therapy for Primary Immunodeficiencies – Prof Fabio Candotti

17:30-18:30 | Industry-Sponsored Symposium

20.00 | Congress Dinner – Venue: Francouzská Municipal House

8:00-9:00 | Industry-Sponsored Symposium

9.00-10.30 | Session 6: The Current Status of Gene Therapy in PID

Chairs: Prof Fabio Candotti and Otilia Stanga

  • Lecture 1: Harnessing the Power of Gene Addition: a Vintage Tool for Contemporary IEI Cure – Prof Marina Cavazzana
  • Lecture 2: Can We Cure Genetic Diseases by Rewriting DNA? – Prof Ayal Hendel
  • Lecture 3: CAR T and CAR NK Approaches in Immune Diseases – Dr Thanyavi Chinsuwan
  • Lecture 4: New Avenues for Gene Editing / Genomic Medicine in PIDs (New Technologies) – Prof Claire Booth

10.30-11.00 | Coffee Break and Guided Poster Walk 4

  • PID Management of Comorbidities and Organ Complications, including the Liver, guided by Prof Martin Van Hagen
  • Autoinflammation, Autoimmunity and Primary Immune Regulatory Disorders (PIRDs) guided by Dr Tadej Avcin

11.00-12.30 | Session 7: Ethics Session: Philosophical and Ethical Considerations to Clinical Boundaries in Genomics

Chairs: Dr Lizzy Rivers and Roberta Anido

12.30-13.30 | Industry-Sponsored Symposium

12.30-13.45 | Lunch and Poster Walk Industry-Sponsored Symposium

13.45-14.45  | Industry-Sponsored Symposium

14.45-15.15 | Young PID Investigators: Poster Winners’ Session

Chairs: Dr Lorena Regairaz and Martine Pergent

15.15-15.45 | Coffee break and Guided Poster Walk 5

15.45-17.00 | Session 8: “Mystic liver” – Management of Hepatic Manifestations

Chairs: Prof Martin Van Hagen and Tracy Shaw

17.00-17.45 | Closure Talk – Seeing the Whole Picture: A Comprehensive Approach to Genetic Evaluation

Chairs: Dr Nizar Mahlaoui