Prof Stuart Tangye

Prof Tangye studies the biology of human immune cells in health and disease, aiming to understand how defects in single genes – inborn errors of immunity – result in various immune diseases. His research outcomes include elucidating critical roles for specific genes in the generation and function of human memory B cells and CD4+ T cells in response to infection and/or vaccination, and anti-viral immunity mediated by CD8⁺ T cells. These findings have revealed defects in lymphocyte function in distinct immune deficient conditions and have delineated functional requirements for effective host defence against specific infectious diseases.

Prof Tangye has published ~290 peer-reviewed articles, been funded by the NHMRC and Medical Research Future Fund of Australia, Cancer Council NSW, NIAID/NIH, Jeffrey Modell Foundation, and the Job Research Foundation. He holds positions on editorial boards of J Exp Med, J Clin Immunol, Blood and Front Immunol, and has been a member of the International Union of Immunological Societies Expert Committee of Inborn Errors of Immunity since 2017 (including being Chair 2018-2023). Since 2018, he has been a Clarivate Highly Cited Researcher.

His contributions to research have been recognized by being awarded the 2011 Gottschalk Medal from the Australian Academy of Sciences, Faculty of Science Alumni Award (2013), Fulbright Senior Scholarship (2015), the Presidential Award from the Clinical Immunology Society (USA, 2019), an NHMRC Research Excellence Award (2020), the Australian Museum Eureka Prize for Scientific Research (2024), and the NSW Premier’s Prize for Excellence in Medical Biological Sciences (2024). He was elected as a Fellow of the Australian Academy of Health and Medical Sciences and of the Clinical Immunology Society of North America in 2023. When he is not at work, he enjoys surfing, cycling, swimming, playing guitar and being a dad to three amazing children!